Article
Para-phenylenediamine and allergic sensitization: risk modification by N-acetyltransferase 1 and 2 genotypes.
The British journal of dermatology - 1 Nov 2009
Blömeke B, Brans R, Coenraads P-J, Dickel H, Bruckner T, Hein D W, Heesen M, Merk H-F, Kawakubo Y
Abstract excerpt
BACKGROUND: Para-phenylenediamine (PPD) is a common contact sensitizer causing allergic contact dermatitis, a major skin problem. As PPD may need activation to become immunogenic, the balance between activation and/or detoxification processes may influence an individual's susceptibility. PPD is acetylated and the metabolites do not activate dendritic-like cells and T cells of PPD-sensitized individuals....
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