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Article

Metabolic activation of heterocyclic aromatic amines catalyzed by human arylamine N-acetyltransferase isozymes (NAT1 and NAT2) expressed in Salmonella typhimurium.

Carcinogenesis - 1 Mar 1995

Wild D, Feser W, Michel S, Lord H L, Josephy P D

Abstract excerpt

Heterocyclic aromatic amines formed during the cooking of meat and meat-derived products can be activated to reactive metabolites which bind to DNA, induce mutations and cause tumors in animals. A principal route of metabolic activation is N-oxidation to hydroxylamines, and their subsequent activation by acetyltransferase-catalyzed O-acetylation. We have used mutagenicity assays to study O-acetylation of...

Topics

Acetylation
Amines
Arylamine N-Acetyltransferase
Biotransformation
Catalysis
Cloning, Molecular
Heterocyclic Compounds
Humans
Isoenzymes
Mutagens
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombinant Proteins

Salmonella typhimurium

Source

Identifiers

PMID: 7697826
DOI: 10.1093/carcin/16.3.643

Genes

NAT2
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7697826-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Metabolic activation of heterocyclic aromatic amines catalyzed by human arylamine N-acetyltransferase isozymes (NAT1 and NAT2) expressed in Salmonella typhimurium.PMID 7697826Read ↗

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[Heterocyclic aromatic amines, food-derived mutagens: metabolism and relevance to cancer susceptibility].Semantic proximity Read ↗

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