Host defense against cholera toxin is strongly CD4+ T cell dependent.

doi:10.1128/iai.59.10.3630-3638.1991

Back to search

Article

Host defense against cholera toxin is strongly CD4+ T cell dependent.

Infection and immunity - 1 Oct 1991

Hörnqvist E, Goldschmidt T J, Holmdahl R, Lycke N

Abstract excerpt

This study investigates the role of CD4+ T cells in host defense against cholera enterotoxin-induced diarrhea. Antitoxin immunoglobulin A formation and gut protection against cholera toxin (CT) following oral immunizations with CT were evaluated in normal mice and mice that had been depleted of C...

Topics

Animals
Antibodies, Bacterial
Antibodies, Monoclonal
CD4 Antigens
Cholera Toxin
Diarrhea
Female
Immunization
Interferon-gamma
Intestines
Lymphocyte Depletion
Mice
Mice, Inbred C57BL
Phenotype
T-Lymphocytes

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.