Article
Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junctions.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 1991
Fasano A, Baudry B, Pumplin D W, Wasserman S S, Tall B D, Ketley J M, Kaper J B
Abstract excerpt
Attenuated Vibrio cholerae vaccine strains specifically mutated in genes encoding cholera toxin (CT) are still capable of causing mild to moderate diarrhea. Culture supernatants of V. cholerae strains, both CT-positive and CT-negative, were examined in Ussing chambers, and a toxin was found that increases the permeability of the small intestinal mucosa by affecting the structure of the intercellular tight...
Topics
- Animals
- Cholera Toxin
- Enterotoxins
- Ileum
- Intercellular Junctions
- Intestinal Mucosa
- Male
- Microscopy, Electron
- Mutation
- Rabbits
- Vibrio cholerae