Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help.

doi:10.1084/jem.175.3.695

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Article

Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help.

The Journal of experimental medicine - 1 Mar 1992

Fujihashi K, Taguchi T, Aicher W K, McGhee J R, Bluestone J A, Eldridge J H, Kiyono H

Abstract excerpt

Past work has shown that a subset of effector T cells with unique characteristics could abrogate hapten- or antigen-induced tolerance, and the reconstitution of this immune response has been termed contrasuppression. We have studied contrasuppression in a model of oral tolerance (OT) in which adoptively transferred antigen-specific T contrasuppressor (Tcs) cells reverse OT and result in antibody responses to the...

Topics

Animals
Antibody Formation
Antigens, Surface
B-Lymphocytes
Cell Adhesion
Digestive System
Epithelial Cells
Interleukin-5
Intestinal Mucosa
Lectins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocytes

Mice

Mice, Inbred C3H

Phenotype

Plant Lectins

Receptors, Antigen, T-Cell, alpha-beta

Receptors, Antigen, T-Cell, gamma-delta

T-Lymphocyte Subsets

Source

Open in PubMed Open full text

Identifiers

PMID: 1531495
DOI: 10.1084/jem.175.3.695
PMCID: PMC2119151

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1531495-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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