Article
Non-replicating mucosal and systemic vaccines: quantitative and qualitative differences in the Ag-specific CD8(+) T cell population in different tissues.
Vaccine - 29 Mar 2004
Qimron Udi, Paul Lada, Bar-Haim Erez, Bloushtain Noga, Eisenbach Lea, Staats Herman F, Porgador Angel
Abstract excerpt
Directed dissemination of Ag-specific CD8(+) T cells to infected organs or cancerous tissues is a prerequisite for optimal immunotherapy. Ag-specific CD8(+) T cells were quantitated in systemic and mucosal tissues after nasal, rectal, or cutaneous immunization with CTL epitope peptide and the adjuvant cholera toxin (CT). Mucosal and cutaneous immunization induced Ag-specific CD8(+) lymphocytes that were...
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