Article
The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure.
Cell cycle (Georgetown, Tex.) - 15 Dec 2008
Maller Schulman Betsy R, Liang Xianping, Stahlhut Carlos, DelConte Casey, Stefani Giovanni, Slack Frank J
Abstract excerpt
In the nematode Caenorhabditis elegans, the let-7 microRNA (miRNA) controls the timing of key developmental events and terminal differentiation in part by directly regulating lin-41. C. elegans lin-41 mutants display precocious cell cycle exit and terminal differentiation of epidermal skin cells. lin-41 orthologues are found in more complex organisms including both mice and humans, but their roles are not known....
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