Article
The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target.
Developmental cell - 1 May 2003
Lin Shin-Yi, Johnson Steven M, Abraham Mary, Vella Monica C, Pasquinelli Amy, Gamberi Chiara, Gottlieb Ellen, Slack Frank J
Abstract excerpt
hunchback regulates the temporal identity of neuroblasts in Drosophila. Here we show that hbl-1, the C. elegans hunchback ortholog, also controls temporal patterning. Furthermore, hbl-1 is a probable target of microRNA regulation through its 3'UTR. hbl-1 loss-of-function causes the precocious expression of adult seam cell fates. This phenotype is similar to loss-of-function of lin-41, a known target of the let-7...
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