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Article

Stem cell marker prominin‐1 regulates branching morphogenesis, but not regenerative capacity, in the mammary gland

11 Jan 2011

Abstract excerpt

Prominin-1 (Prom1) is recognized as a stem cell marker in several tissues, including blood, neuroepithelium, and gut, and in human and mouse embryos and many cancers. Although Prom1 is routinely used as a marker for isolating stem cells, its biological function remains unclear. Here we use a knockout model to investigate the role of Prom1 in the mammary gland. We demonstrate that complete loss of Prom1 does not...

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PMID: 21337465
DOI: 10.1002/dvdy.22539

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