Gains in power for exhaustive analyses of haplotypes using variable-sized sliding window strategy: a comparison of association-mapping strategies.

doi:10.1038/ejhg.2008.244

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Article

Gains in power for exhaustive analyses of haplotypes using variable-sized sliding window strategy: a comparison of association-mapping strategies.

European journal of human genetics : EJHG - 1 Jun 2009

Guo Yanfang, Li Jian, Bonham Aaron J, Wang Yuping, Deng Hongwen

Abstract excerpt

Linkage disequilibrium (LD)-based association mapping is often performed by analyzing either individual SNPs or block-based multi-SNP haplotypes. Sliding windows of several fixed sizes (in terms of SNP numbers) were also applied to a few simulated or real data sets. In comparison, exhaustively testing based on variable-sized sliding windows (VSW) of all possible sizes of SNPs over a genomic region has the best...

Topics

Algorithms
Cluster Analysis
Computational Biology
Disease
Genome-Wide Association Study
Haplotypes
Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 19092774
DOI: 10.1038/ejhg.2008.244
PMCID: PMC2746379

Genes

BLK
LRP5

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