Article
Gains in power for exhaustive analyses of haplotypes using variable-sized sliding window strategy: a comparison of association-mapping strategies.
European journal of human genetics : EJHG - 1 Jun 2009
Guo Yanfang, Li Jian, Bonham Aaron J, Wang Yuping, Deng Hongwen
Abstract excerpt
Linkage disequilibrium (LD)-based association mapping is often performed by analyzing either individual SNPs or block-based multi-SNP haplotypes. Sliding windows of several fixed sizes (in terms of SNP numbers) were also applied to a few simulated or real data sets. In comparison, exhaustively testing based on variable-sized sliding windows (VSW) of all possible sizes of SNPs over a genomic region has the best...
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