Exhaustive allelic transmission disequilibrium tests as a new approach to genome-wide association studies.

doi:10.1038/ng1457

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Article

Exhaustive allelic transmission disequilibrium tests as a new approach to genome-wide association studies.

Nature genetics - 1 Nov 2004

Lin Shin, Chakravarti Aravinda, Cutler David J

Abstract excerpt

Genome-wide disease-association mapping has been heralded as the study design of the next generation, but the lack of analytical methods to use genotype data fully is a large stumbling block. Here we describe an algorithm and statistical method that efficiently and exhaustively exploits haplotype information by subjecting alleles (a marker or contiguous sets of markers) from sliding windows of all sizes to...

Topics

Algorithms
Alleles
Chromosome Mapping
Computer Simulation
Genetic Diseases, Inborn
Genetic Markers
Genetic Predisposition to Disease
Genome, Human
Haplotypes
Hirschsprung Disease
Humans
Models, Genetic
Models, Statistical
Polymorphism, Single Nucleotide
Sensitivity and Specificity

Source

Open in PubMed

Identifiers

PMID: 15502828
DOI: 10.1038/ng1457

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