Article
Screening for recently selected alleles by analysis of human haplotype similarity.
American journal of human genetics - 1 Jan 2006
Hanchard Neil A, Rockett Kirk A, Spencer Chris, Coop Graham, Pinder Margaret, Jallow Muminatou, Kimber Martin, McVean Gil, Mott Richard, Kwiatkowski Dominic P
Abstract excerpt
There is growing interest in the use of haplotype-based methods for detecting recent selection. Here, we describe a method that uses a sliding window to estimate similarity among the haplotypes associated with any given single-nucleotide polymorphism (SNP) allele. We used simulations of natural selection to provide estimates of the empirical power of the method to detect recently selected alleles and found it to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.