Burkitt lymphoma cell lines are prone to recombination in the switch region of the Ig mu heavy chain locus.

doi:10.1016/0167-4781(91)90044-m

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Burkitt lymphoma cell lines are prone to recombination in the switch region of the Ig mu heavy chain locus.

Biochimica et biophysica acta - 27 Aug 1991

Middleton P G, Williamson I K, Taylor J J, Rowe D, Guy K

Abstract excerpt

Different recombinations have been found at the Ig heavy chain gene loci in a number of sublines of the Burkitt lymphoma (BL) cell line Namalwa, following prolonged in vitro culture. The Namalwa sublines examined are DNA fingerprint-identical and derived from a monoclonal source. Recombinant DNA...

Topics

B-Lymphocytes
Base Sequence
Blotting, Southern
Burkitt Lymphoma
Cloning, Molecular
Gene Rearrangement
Humans
Immunoglobulin Joining Region
Immunoglobulin M
Immunoglobulin Switch Region
Immunoglobulin Variable Region
Immunoglobulin mu-Chains
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Recombination, Genetic
Restriction Mapping
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1909179
DOI: 10.1016/0167-4781(91)90044-m

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1909179-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics