Article
Burkitt lymphoma cell lines are prone to recombination in the switch region of the Ig mu heavy chain locus.
Biochimica et biophysica acta - 27 Aug 1991
Middleton P G, Williamson I K, Taylor J J, Rowe D, Guy K
Abstract excerpt
Different recombinations have been found at the Ig heavy chain gene loci in a number of sublines of the Burkitt lymphoma (BL) cell line Namalwa, following prolonged in vitro culture. The Namalwa sublines examined are DNA fingerprint-identical and derived from a monoclonal source. Recombinant DNA clones were used to map the Ig heavy chain gene mutations to a region between the VDJ and C mu segment of the locus....
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