Recurrent mutation of immunoglobulin and c-myc genes and differential expression of cell surface antigens occur in variant cell lines derived from a Burkitt lymphoma.

doi:10.1002/ijc.2910450120

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Recurrent mutation of immunoglobulin and c-myc genes and differential expression of cell surface antigens occur in variant cell lines derived from a Burkitt lymphoma.

International journal of cancer - 15 Jan 1990

Guy K, Middleton P G, Bansal N S, Ross J A, Steel C M

Abstract excerpt

The phenotypic and molecular genetic characteristics of 4 variant sublines of the Burkitt lymphoma cell line Namalwa have been examined. The sublines are DNA-fingerprint-identical and derived from a monoclonal tumour, as shown by a rearrangement of the T-cell-receptor beta-chain gene common to th...

Topics

Antibodies, Monoclonal
Antigens, Neoplasm
Antigens, Surface
Burkitt Lymphoma
Cell Line
DNA, Neoplasm
Flow Cytometry
Gene Expression Regulation, Neoplastic
Genes, Immunoglobulin
Genetic Variation
Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Histocompatibility Antigens Class II

Humans

Immunoglobulin G

Mutation

Oncogenes

Phenotype

RNA, Neoplasm

Source

Open in PubMed

Identifiers

PMID: 2298494
DOI: 10.1002/ijc.2910450120

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2298494-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Recurrent mutation of immunoglobulin and c-myc genes and differential expression of cell surface antigens occur in variant cell lines derived from a Burkitt lymphoma.PMID 2298494Read ↗

Burkitt lymphoma cell lines are prone to recombination in the switch region of the Ig mu heavy chain locus.Semantic proximity Read ↗

Different Epstein-Barr virus-B cell interactions in phenotypically distinct clones of a Burkitt's lymphoma cell line.Semantic proximity Read ↗

Idiotypic variation in a human B lymphoma cell line.Semantic proximity Read ↗

Aberrant expression of HLA class-I antigens in Burkitt lymphoma cells.Semantic proximity Read ↗

Malignant B-cell intra-clonal diversification: following the yarn in the labyrinth.Semantic proximity Read ↗

Genetic background and evolution of relapses in aggressive B-cell lymphomas.Semantic proximity Read ↗

A novel human lymphoma cell line (Deglis) with dual B/T phenotype and gene rearrangements and containing Epstein-Barr virus genomes.Semantic proximity Read ↗

Reframing Burkitt lymphoma: virology not epidemiology defines clinical variantsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.