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Article

Immunoglobulin D switching can occur through homologous recombination in human B cells.

1 Jul 1990

Abstract excerpt

Prototypical class switching in mouse and human immunoglobulin heavy chains occurs through recombination of tandem blocks of short repeats located 5' to each heavy chain constant region (CH) except C delta. Deletion of C mu in immunoglobulin D (IgD)-secreting murine plasmacytomas occurs illegitimately. We demonstrate here that in human IgD-secreting myeloma cells freshly isolated from patient bone marrow and in...

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Identifiers

PMID: 2113175
DOI: 10.1128/mcb.10.7.3690

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