Article
FOXP3/Scurfin gene polymorphism is associated with adult onset type 1 diabetes in Japanese, especially in women and slowly progressive-type patients.
Autoimmunity - 1 Feb 2009
Iwase Kyoko, Shimada Akira, Kawai Toshihide, Okubo Yoshiaki, Kanazawa Yasuhiko, Irie Junichiro, Oikawa Yoichi, Hirose Hiroshi, Maruyama Taro, Itoh Hiroshi
Abstract excerpt
PURPOSE: Some reports have shown that the cause of type 1 diabetes is associated with dysfunction of regulatory T cells (Tregs). The FOXP3/Scurfin gene is known to be a master gene of Tregs. Therefore, we tried to analyze the relation between the gene polymorphism and adult onset type 1 diabetes...
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