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Gender bias in the genetic vulnerability towards type 2 diabetes and diabetic nephropathy: Role of forkhead box Protein3 transcription factor gene variants.

Gene - 30 Mar 2021

Chikoti Swetha, Mahwish Umme Najiya, Raju Sree Bhushan, Gaddam Sumanlatha, Jahan Parveen

Abstract excerpt

Forkhead Box Protein3 Transcription Factor (FOXP3) gene is an essential role player in the function and differentiation of regulatory T cells. Polymorphisms/mutations in FOXP3 gene cause Treg cell dysfunction, promote autoimmunity and inflammation. Based on this presumption, we screened 600 subjects from south India (equal number of diabetic (T2DM), diabetic nephropathy (T2DN) and healthy controls) for promoter...

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Identifiers

PMID: 33444682
DOI: 10.1016/j.gene.2021.145426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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