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Foxp3 gene polymorphisms and haplotypes associate with susceptibility of Graves' disease in Chinese Han population.

International immunopharmacology - 1 Apr 2015

Zheng Lei, Wang XiaoBei, Xu Lijuan, Wang Ning, Cai Pengcheng, Liang Tao, Hu LiHua

Abstract excerpt

BACKGROUND: Foxp3 plays important roles in the pathogenesis of autoimmune diseases. To investigate the association between Foxp3 gene polymorphisms and the susceptibility to Graves' disease (GD) in Chinese Han population, four single nucleotide polymorphisms (SNPs) including -2383, -3279, -3499 in the promoter and IVS9+459 in the intron were genotyped. METHODS: Genotyping was performed by polymerase chain...

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PMID: 25708657
DOI: 10.1016/j.intimp.2015.02.020

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