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Haplotypes of FOXP3 genetic variants are associated with susceptibility, autoantibodies, and TGF-β1 in patients with systemic lupus erythematosus.

Scientific reports - 8 Mar 2021

Stadtlober Nicole Perugini, Flauzino Tamires, da Rosa Franchi Santos Lorena Flor, Iriyoda Tatiana Mayumi Veiga, Costa Neide Tomimura, Lozovoy Marcell Alysson Batisti, Dichi Isaias, Reiche Edna Maria Vissoci, Simão Andréa Name Colado

Abstract excerpt

The aim of this study was to evaluate the association of rs2232365 (-924 G > A) and rs3761548 (-3279 C > A) FOXP3 variants with systemic lupus erythematosus (SLE) susceptibility, TGF-β1 plasma levels, autoantibodies, and LN nephritis, and SLE disease activity index (SLEDAI). The study included 196 SLE female patients and 157 female controls. FOXP3 variants were determined with polymerase chain...

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Identifiers

PMID: 33686190
DOI: 10.1038/s41598-021-84832-3
PMCID: PMC7940633

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