Article
Frequency of FLT3 mutations in childhood acute lymphoblastic leukemia.
Medical oncology (Northwood, London, England) - 1 Dec 2009
Braoudaki M, Karpusas M, Katsibardi K, Papathanassiou Ch, Karamolegou K, Tzortzatou-Stathopoulou F
Abstract excerpt
FLT3 mutations are occasionally observed in acute lymphoblastic leukemia (ALL). These most frequently manifest as internal tandem duplications (ITD) and activation loop (AL) mutations. This study investigated the incidence of FLT3 mutations in 86 pediatric patients diagnosed with ALL and the co-presence of common RAS mutations. A 2.3% (2/86) FLT3/AL mutation rate in terms of total ALL cases and a 22% (2/9)...
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