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Article

FLT3 mutations in childhood acute lymphoblastic leukemia.

Blood - 1 May 2004

Armstrong Scott A, Mabon Meghann E, Silverman Lewis B, Li Aihong, Gribben John G, Fox Edward A, Sallan Stephen E, Korsmeyer Stanley J

Abstract excerpt

Activating mutations of the FLT3 receptor tyrosine kinase are common in acute myelogenous leukemia (AML) but are rare in adult acute lymphoblastic leukemia (ALL). We have recently shown that FLT3 is highly expressed and often mutated in ALLs with rearrangement of the mixed lineage leukemia (MLL) gene on chromosome 11q23. Because hyperdiploid ALL samples also show high-level expression of FLT3, we searched for the...

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Share to Core Binding Factor Alpha 2 Subunit
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to fms-Like Tyrosine Kinase 3

Share to Oncogene Proteins, Fusion

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Receptor Protein-Tyrosine Kinases

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Source

Identifiers

PMID: 14670924
DOI: 10.1182/blood-2003-07-2441

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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