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Article

Incidence of FLT3 and nucleophosmin gene mutations in childhood acute myeloid leukemia: Serbian experience and the review of the literature.

Medical oncology (Northwood, London, England) - 1 Sept 2010

Krstovski Nada, Tosic Natasa, Janic Dragana, Dokmanovic Lidija, Kuzmanovic Milos, Spasovski Vesna, Pavlovic Sonja

Abstract excerpt

Mutations in the fms-like tyrosine kinase 3 (FLT3) gene (internal tandem duplication (ITD) and point mutation in the tyrosine kinase domain, FLT3/D835) as well as the nucleophosmin (NPM1) gene are the most common abnormalities in adult acute myeloid leukemia (AML). Their significance in pediatric AML is still unclear. In this study we evaluated the frequency of FLT3 and NPM1 mutations in childhood AML. We also...

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Source

Identifiers

PMID: 19557552
DOI: 10.1007/s12032-009-9261-5

Genes

FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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