Article
SAS-4 is a C. elegans centriolar protein that controls centrosome size.
Cell - 21 Feb 2003
Kirkham Matthew, Müller-Reichert Thomas, Oegema Karen, Grill Stephan, Hyman Anthony A
Abstract excerpt
Centrosomes consist of a centriole pair surrounded by pericentriolar material (PCM). Previous work suggested that centrioles are required to organize PCM to form a structurally stable organelle. Here, we characterize SAS-4, a centriole component in Caenorhabditis elegans. Like tubulin, SAS-4 is incorporated into centrioles during their duplication and remains stably associated thereafter. In the absence of SAS-4,...
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