Article
Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations.
Human heredity - 1 Jan 2009
Chung Wendy K, Patki Amit, Matsuoka Naoki, Boyer Bert B, Liu Nianjun, Musani Solomon K, Goropashnaya Anna V, Tan Perciliz L, Katsanis Nicholas, Johnson Stephen B, Gregersen Peter K, Allison David B, Leibel Rudolph L, Tiwari Hemant K
Abstract excerpt
OBJECTIVE: Human adiposity is highly heritable, but few of the genes that predispose to obesity in most humans are known. We tested candidate genes in pathways related to food intake and energy expenditure for association with measures of adiposity. METHODS: We studied 355 genetic variants in 30 candidate genes in 7 molecular pathways related to obesity in two groups of adult subjects: 1,982 unrelated European...
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