Article
Fat mass and obesity-associated gene (FTO) is linked to higher plasma levels of the hunger hormone ghrelin and lower serum levels of the satiety hormone leptin in older adults.
Diabetes - 1 Nov 2014
Benedict Christian, Axelsson Tomas, Söderberg Stefan, Larsson Anders, Ingelsson Erik, Lind Lars, Schiöth Helgi B
Abstract excerpt
The mechanisms through which common polymorphisms in the fat mass and obesity-associated gene (FTO) drive the development of obesity in humans are poorly understood. Using cross-sectional data from 985 older people (50% females) who participated at age 70 years in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS), circulating levels of ghrelin and leptin were measured after an overnight...
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