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MC 1R variation and melanoma risk in relation to host/clinical and environmental factors in CDKN 2A positive and negative melanoma patients

7 Jun 2012

Abstract excerpt

Host, environmental and genetic factors differently modulate cutaneous melanoma (CM) risk across populations. Currently, the main genetic risk determinants are germline mutations in the major known high-risk susceptibility genes, CDKN2A and CDK4, and variants of the low-risk gene MC1R, which is key in the pigmentation process. This case-control study aimed at investigating the influence of the main host and...

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Share to Cutaneous Melanoma Detection and Management
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22804906
DOI: 10.1111/j.1600-0625.2012.01549.x

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