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Article

Synthetic lethal interactions for the development of cancer therapeutics: biological and methodological advancements.

Human genetics - 1 Dec 2010

Mizuarai Shinji, Kotani Hidehito

Abstract excerpt

Synthetic lethal interaction is defined as a combination of two mutations that is lethal when present in the same cell; each individual mutation is non-lethal. Synthetic lethal interactions attract attention in cancer research fields since the discovery of synthetic lethal genes with either oncogenes or tumor suppressor genes (TSGs) provides novel cancer therapeutic targets. Due to the selective lethal effect on...

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Identifiers

PMID: 20976469
DOI: 10.1007/s00439-010-0900-x

Genes

BRCA1
PARP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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