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Article

Synthetic lethal interactions for the development of cancer therapeutics: biological and methodological advancements.

Human genetics - 1 Dec 2010

Mizuarai Shinji, Kotani Hidehito

Abstract excerpt

Synthetic lethal interaction is defined as a combination of two mutations that is lethal when present in the same cell; each individual mutation is non-lethal. Synthetic lethal interactions attract attention in cancer research fields since the discovery of synthetic lethal genes with either oncog...

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Source

Identifiers

PMID: 20976469
DOI: 10.1007/s00439-010-0900-x

Genes

BRCA1
PARP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20976469-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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