Article
The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells.
The Journal of cell biology - 15 Dec 2008
Feng Weiyi, McCabe N Patrick, Mahabeleshwar Ganapati H, Somanath Payaningal R, Phillips David R, Byzova Tatiana V
Abstract excerpt
Angiogenesis is dependent on the coordinated action of numerous cell types. A key adhesion molecule expressed by these cells is the alpha(v)beta(3) integrin. Here, we show that although this receptor is present on most vascular and blood cells, the key regulatory function in tumor and wound angiogenesis is performed by beta(3) integrin on bone marrow-derived cells (BMDCs) recruited to sites of neovascularization....
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