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β3-integrin–deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival

15 Jan 1999

Abstract excerpt

beta3 integrins have been implicated in a wide variety of functions, including platelet aggregation and thrombosis (alphaIIbbeta3) and implantation, placentation, angiogenesis, bone remodeling, and tumor progression (alphavbeta3). The human bleeding disorder Glanzmann thrombasthenia (GT) can result from defects in the genes for either the alphaIIb or the beta3 subunit. In order to develop a mouse model of this...

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PMID: 9916135
DOI: 10.1172/jci5487

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