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Article

Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain.

Proceedings of the National Academy of Sciences of the United States of America - 30 Jun 2009

Lorger Mihaela, Krueger Joseph S, O'Neal Melissa, Staflin Karin, Felding-Habermann Brunhilde

Abstract excerpt

The incidence of brain metastasis is rising and poses a severe clinical problem, as we lack effective therapies and knowledge of mechanisms that control metastatic growth in the brain. Here we demonstrate a crucial role for high-affinity tumor cell integrin alpha(v)beta(3) in brain metastatic growth and recruitment of blood vessels. Although alpha(v)beta(3) is frequently up-regulated in primary brain tumors and...

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Source

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Identifiers

PMID: 19541645
DOI: 10.1073/pnas.0903035106
PMCID: PMC2697113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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