The biological functions of beta3 integrins.

Abstract excerpt

Integrins comprise a large family of alphabeta heterodimeric cell-surface receptors that are found in many animal species. They are expressed on a wide variety of cells. There are two members in the beta3 integrin family: alphaIIb beta3 and alpha(v)beta3. This class of adhesion receptors mediates cell-cell and cell-extracellular matrix interactions. Dysregulation of the beta3 integrins is involved in the...