Article
Integrin activation controls metastasis in human breast cancer.
Proceedings of the National Academy of Sciences of the United States of America - 13 Feb 2001
Felding-Habermann B, O'Toole T E, Smith J W, Fransvea E, Ruggeri Z M, Ginsberg M H, Hughes P E, Pampori N, Shattil S J, Saven A, Mueller B M
Abstract excerpt
Metastasis is the primary cause of death in human breast cancer. Metastasis to bone, lungs, liver, and brain involves dissemination of breast cancer cells via the bloodstream and requires adhesion within the vasculature. Blood cell adhesion within the vasculature depends on integrins, a family of transmembrane adhesion receptors, and is regulated by integrin activation. Here we show that integrin alpha v beta 3...
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