Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conditional knockdown of integrin beta-3 reveals its involvement in osteolytic and soft tissue lesions of breast cancer skeletal metastasis

20 Oct 2020

Abstract excerpt

Integrin β3 (ITGB3) is probably related to skeletal metastasis, which is the most frequent complication in breast cancer progression. We aimed to define its role and suitability as target for anti-metastatic therapy. We generated two MDA-MB-231 cell clones with conditional miRNA-mediated ITGB3 knockdown for analyzing the resulting effects in vitro regarding mRNA expression, proliferation and migration, as well...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Cell Adhesion Molecules Research
Share to Extracellular vesicles in disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33083904
DOI: 10.1007/s00432-020-03428-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conditional knockdown of integrin beta-3 reveals its involvement in osteolytic and soft tissue lesions of breast cancer skeletal metastasisPMID 33083904Read ↗

Targeting the Metastatic Bone Microenvironment by MicroRNAsSemantic proximity Read ↗

Integrinβ-1 in disorders and cancers: molecular mechanisms and therapeutic targetsSemantic proximity Read ↗

Bone sialoprotein‐αvβ3 integrin axis promotes breast cancer metastasis to the boneSemantic proximity Read ↗

Integrins and Exosomes, a Dangerous Liaison in Cancer ProgressionSemantic proximity Read ↗

Multidimensional analysis to elucidate the possible mechanism of bone metastasis in breast cancerSemantic proximity Read ↗

microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in TherapySemantic proximity Read ↗

Breast cancer invasion by microRNAs aidSemantic proximity Read ↗

Junctional adhesion molecular 3 (JAM3) is a novel tumor suppressor and improves the prognosis in breast cancer brain metastasis via the TGF-β/Smad signal pathwaySemantic proximity Read ↗

Cancer-Associated Exosomal CBFB Facilitates the Aggressive Phenotype, Evasion of Oxidative Stress, and Preferential Predisposition to Bone Prometastatic Factor of Breast Cancer Progression.Semantic proximity Read ↗

Tumour-derived miRNAs and bone metastasisSemantic proximity Read ↗

Integrin alpha9 emerges as a key therapeutic target to reduce metastasis in rhabdomyosarcoma and neuroblastomaSemantic proximity Read ↗

Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promotersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.