Article
Functional differentiation of tbf1 orthologues in fission and budding yeasts.
Eukaryotic cell - 1 Feb 2009
Cockell Moira M, Lo Presti Libera, Cerutti Lorenzo, Cano Del Rosario Elena, Hauser Philippe M, Simanis Viesturs
Abstract excerpt
In Saccharomyces cerevisiae, TBF1, an essential gene, influences telomere function but also has other roles in the global regulation of transcription. We have identified a new member of the tbf1 gene family in the mammalian pathogen Pneumocystis carinii. We demonstrate by transspecies complementation that its ectopic expression can provide the essential functions of Schizosaccharomyces pombe tbf1 but that there...
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