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Article

Functional characterization of Pneumocystis carinii brl1 by transspecies complementation analysis.

Eukaryotic cell - 1 Dec 2007

Lo Presti Libera, Cockell Moira, Cerutti Lorenzo, Simanis Viesturs, Hauser Philippe M

Abstract excerpt

Pneumocystis jirovecii is a fungus which causes severe opportunistic infections in immunocompromised humans. The brl1 gene of P. carinii infecting rats was identified and characterized by using bioinformatics in conjunction with functional complementation in Saccharomyces cerevisiae and Schizosaccharomyces pombe. The ectopic expression of this gene rescues null alleles of essential nuclear membrane proteins of...

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Identifiers

PMID: 17993570
DOI: 10.1128/EC.00321-07
PMCID: PMC2168235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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