Article
Sec6p anchors the assembled exocyst complex at sites of secretion.
Molecular biology of the cell - 1 Feb 2009
Songer Jennifer A, Munson Mary
Abstract excerpt
The exocyst is an essential protein complex required for targeting and fusion of secretory vesicles to sites of exocytosis at the plasma membrane. To study the function of the exocyst complex, we performed a structure-based mutational analysis of the Saccharomyces cerevisiae exocyst subunit Sec6p. Two "patches" of highly conserved residues are present on the surface of Sec6p; mutation of either patch does not...
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