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Article

Polar assembly and scaffolding proteins of the virulence‐associated ESX‐1 secretory apparatus in mycobacteria

11 Jan 2012

Abstract excerpt

The ESX-1 secretion system is required for pathogenicity of Mycobacterium tuberculosis (Mtb). Despite considerable research, little is known about the structural components of ESX-1, or how these proteins are assembled into the active secretion apparatus. Here, we exploit the functionally related ESX-1 apparatus of Mycobacterium smegmatis (Ms) to show that fluorescently tagged proteins required for ESX-1 activity...

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PMID: 22233444
DOI: 10.1111/j.1365-2958.2011.07958.x

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