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Genetic variants in fanconi anemia pathway genes BRCA2 and FANCA predict melanoma survival.

The Journal of investigative dermatology - 1 Feb 2015

Yin Jieyun, Liu Hongliang, Liu Zhensheng, Wang Li-E, Chen Wei V, Zhu Dakai, Amos Christopher I, Fang Shenying, Lee Jeffrey E, Wei Qingyi

Abstract excerpt

Cutaneous melanoma (CM) is the most lethal skin cancer. The Fanconi anemia (FA) pathway involved in DNA crosslink repair may affect CM susceptibility and prognosis. Using data derived from published genome-wide association study, we comprehensively analyzed the associations of 2,339 common single-nucleotide polymorphisms (SNPs) in 14 autosomal FA genes with overall survival (OS) in 858 CM patients. By performing...

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Computational Biology
Fanconi Anemia
Fanconi Anemia Complementation Group A Protein
Genes, BRCA2
Melanoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proportional Hazards Models

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Open in PubMed Open full text

Identifiers

PMID: 25243787
DOI: 10.1038/jid.2014.416
PMCID: PMC4289462

Genes

BRCA2
FANCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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