Article
Inherited variation in the PARP1 gene and survival from melanoma.
International journal of cancer - 1 Oct 2014
Davies John R, Jewell Rosalyn, Affleck Paul, Anic Gabriella M, Randerson-Moor Juliette, Ozola Aija, Egan Kathleen M, Elliott Faye, García-Casado Zaida, Hansson Johan, Harland Mark, Höiom Veronica, Jian Guan, Jönsson Göran, Kumar Rajiv, Nagore Eduardo, Wendt Judith, Olsson Håkan, Park Jong Y, Patel Poulam, Pjanova Dace, Puig Susana, Schadendorf Dirk, Sivaramakrishna Rachakonda P, Snowden Helen, Stratigos Alexander J, Bafaloukos Dimitrios, Ogbah Zighereda, Sucker Antje, Van den Oord Joost J, Van Doorn Remco, Walker Christy, Okamoto Ichiro, Wolter Pascal, Barrett Jennifer H, Timothy Bishop D, Newton-Bishop Julia
Abstract excerpt
We report the association of an inherited variant located upstream of the poly(adenosine diphosphate-ribose) polymerase 1 (PARP1) gene (rs2249844), with survival in 11 BioGenoMEL melanoma cohorts. The gene encodes a protein involved in a number of cellular processes including single-strand DNA repair. Survival analysis was conducted for each cohort using proportional hazards regression adjusting for factors known...
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