Article
A systematic genome-wide screen for mutations affecting organogenesis in Medaka, Oryzias latipes.
Mechanisms of development - 1 Jul 2004
Furutani-Seiki Makoto, Sasado Takao, Morinaga Chikako, Suwa Hiroshi, Niwa Katsutoshi, Yoda Hiroki, Deguchi Tomonori, Hirose Yukihiro, Yasuoka Akihito, Henrich Thorsten, Watanabe Tomomi, Iwanami Norimasa, Kitagawa Daiju, Saito Kota, Asaka Satoshi, Osakada Masakazu, Kunimatsu Sanae, Momoi Akihiro, Elmasri Harun, Winkler Christoph, Ramialison Mirana, Loosli Felix, Quiring Rebecca, Carl Matthias, Grabher Clemens, Winkler Sylke, Del Bene Filippo, Shinomiya Ai, Kota Yasuko, Yamanaka Toshiyuki, Okamoto Yasuko, Takahashi Katsuhito, Todo Takeshi, Abe Keiko, Takahama Yousuke, Tanaka Minoru, Mitani Hiroshi, Katada Toshiaki, Nishina Hiroshi, Nakajima Noboru, Wittbrodt Joachim, Kondoh Hisato
Abstract excerpt
A large-scale mutagenesis screen was performed in Medaka to identify genes acting in diverse developmental processes. Mutations were identified in homozygous F3 progeny derived from ENU-treated founder males. In addition to the morphological inspection of live embryos, other approaches were used to detect abnormalities in organogenesis and in specific cellular processes, including germ cell migration, nerve tract...
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