Back to search

Article

A genetic model of congenital intestinal atresia in medaka ( <i>Oryzias latipes</i> ) implicates Mypt1 in epithelial organisation

2021-12-11

Abstract excerpt

Congenital intestinal atresia (IA) is a birth defect characterised by the absence or closure of part of the intestine. Although genetic factors are implicated, mechanistic understanding has been hindered by the lack of suitable animal models. Here, we describe a medaka ( Oryzias latipes ) mutant, generated by N-ethyl-N-nitrosourea (ENU) mutagenesis, that develops IA during embryogenesis. Positional cloning identi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b4308cbf-b11a-531d-b888-4671950402bc
DOI
10.1101/2021.12.10.472183
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A genetic model of congenital intestinal atresia in medaka ( <i>Oryzias latipes</i> ) implicates Mypt1 in epithelial organisationDOI 10.1101/2021.12.10.472183
A genetic model of congenital intestinal atresia implicates Mypt1 in epithelial organisation.Semantic proximity
A lmod1a mutation causes megacystis microcolon intestinal hypoperistalsis in a CRISPR/Cas9-modified zebrafish modelSemantic proximity
A lmod1a mutation causes megacystis microcolon intestinal hypoperistalsis in a CRISPR/Cas9-modified zebrafish model.Semantic proximity
TALPID3/KIAA0586 regulates multiple aspects of neuromuscular patterning during gastrointestinal development in animal models and humanSemantic proximity
Identification of mutations in the<i>MYO9A</i>gene in patients with congenital myasthenic syndromeSemantic proximity
Acute knockdown of extracellular matrix protein Tinagl1 disrupts heart laterality and pronephric cilia in zebrafish embryonic developmentSemantic proximity
Congenital anomalies of the tubular gastrointestinal tractSemantic proximity
Recent advances in the molecular and genetic understanding of congenital gastrointestinal malformations.Semantic proximity
Mutation of smooth muscle myosin causes epithelial invasion and cystic expansion of the zebrafish intestine.Semantic proximity
Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and miceSemantic proximity
A Titin Knock-in model for Hereditary Myopathy with Early Respiratory FailureSemantic proximity
Formation of intestinal atresias in the Fgfr2IIIb-/- mice is not associated with defects in notochord development or alterations in Shh expression.Semantic proximity
Select a neighboring publication to make it the new centre.