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Zebrafish reveal new roles for Fam83f in hatching and the DNA damage-mediated autophagic response

1 Oct 2024

Abstract excerpt

The FAM83 ( Fam ily with sequence similarity 83 ) family is highly conserved in vertebrates, but little is known of the functions of these proteins beyond their association with oncogenesis. Of the family, FAM83F is of particular interest because it is the only membrane-targeted FAM83 protein. When overexpressed, FAM83F activates the canonical Wnt signalling pathway and binds to and stabilizes p53; it therefore...

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PMID: 39437839
DOI: 10.1098/rsob.240194

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