Article
Sp8 regulates inner ear development.
Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 2014
Chung Hyeyoung A, Medina-Ruiz Sofia, Harland Richard M
Abstract excerpt
A forward genetic screen of N-ethyl-N-nitrosourea mutagenized Xenopus tropicalis has identified an inner ear mutant named eclipse (ecl). Mutants developed enlarged otic vesicles and various defects of otoconia development; they also showed abnormal circular and inverted swimming patterns. Positional cloning identified specificity protein 8 (sp8), which was previously found to regulate limb and brain development....
Topics
- Animals
- Base Sequence
- Biomarkers
- Ear
- Ear, Inner
- Embryo, Nonmammalian
- Endonucleases
- Gene Expression Regulation, Developmental
- Molecular Sequence Data
- Morpholinos
- Mutation
- RNA, Messenger
- Trans-Activators
- Transcription Factors
- Xenopus
- Xenopus Proteins