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Article

Sp8 regulates inner ear development.

Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 2014

Chung Hyeyoung A, Medina-Ruiz Sofia, Harland Richard M

Abstract excerpt

A forward genetic screen of N-ethyl-N-nitrosourea mutagenized Xenopus tropicalis has identified an inner ear mutant named eclipse (ecl). Mutants developed enlarged otic vesicles and various defects of otoconia development; they also showed abnormal circular and inverted swimming patterns. Positional cloning identified specificity protein 8 (sp8), which was previously found to regulate limb and brain development....

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Identifiers

PMID: 24722637
DOI: 10.1073/pnas.1319301111
PMCID: PMC4035935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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