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Article

Cellular responses to targeted genomic sequence modification using single-stranded oligonucleotides and zinc-finger nucleases.

DNA repair - 1 Mar 2009

Olsen Petter Angell, Solhaug Anita, Booth James Alexander, Gelazauskaite Monika, Krauss Stefan

Abstract excerpt

Single-stranded oligonucleotides (ssODNs) and zinc-finger nucleases (ZFNs) are two approaches that are being pursued to achieve sequence specific genome modification. ZFNs induce high rates of homologous recombination (HR) between the target sequence and a given donor by introducing site-specific genomic double-strand breaks (DSBs). The mode of action that is used by ssODNs remains largely unknown, but may...

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Identifiers

PMID: 19071233
DOI: 10.1016/j.dnarep.2008.11.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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