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Article

Nuclease-stimulated homologous recombination at the human β-globin gene.

The journal of gene medicine - 1 Jan 2000

Vannocci Tommaso, Kurata Hitoshi, de la Fuente Josu, Roberts Irene A, Porter Andrew C G

Abstract excerpt

BACKGROUND: Mutations in the β-globin gene (HBB) cause haemoglobinopathies where current treatments have serious limitations. Gene correction by homologous recombination (HR) is an attractive approach to gene therapy for such diseases and is stimulated by gene-specific endonucleases, including zinc finger nucleases (ZFNs). Customised nucleases targeting HBB have previously been shown to promote HR-mediated HBB...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24590875
DOI: 10.1002/jgm.2758

Genes

HBB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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