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Article

The nontoxic cell cycle modulator indirubin augments transduction of adeno-associated viral vectors and zinc-finger nuclease-mediated gene targeting.

Human gene therapy - 1 Jan 2013

Rahman Shamim H, Bobis-Wozowicz Sylwia, Chatterjee Debanjana, Gellhaus Katharina, Pars Kaweh, Heilbronn Regine, Jacobs Roland, Cathomen Toni

Abstract excerpt

Parameters that regulate or affect the cell cycle or the DNA repair choice between non-homologous end-joining and homology-directed repair (HDR) are excellent targets to enhance therapeutic gene targeting. Here, we have evaluated the impact of five cell-cycle modulating drugs on targeted genome engineering mediated by DNA double-strand break (DSB)-inducing nucleases, such as zinc-finger nucleases (ZFNs). For a...

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Identifiers

PMID: 23072634
DOI: 10.1089/hum.2012.168
PMCID: PMC3555098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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