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Article

A model of phenotypic susceptibility to tuberculosis: deficient in silico selection of Mycobacterium tuberculosis epitopes by HLA alleles.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG - 1 Sept 2008

Contini S, Pallante M, Vejbaesya S, Park M H, Chierakul N, Kim H S, Saltini C, Amicosante M

Abstract excerpt

HLA-DR allelic variants have been associated with tuberculosis (TB) susceptibility in different populations with risk ratios of 3.7 to 7.2. We hypothesized that the genetic susceptibility to TB depends upon the reduced capability of HLA-class II alleles of TB patients to bind and select peptide antigen from the Mycobacterium tuberculosis (MTB) expressed genome. To test this hypothesis, we developed a software...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19070257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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