Article
HLA-DR binding prediction and experimental evaluation of T-cell epitopes of mycolyl transferase 85B (Ag85B), a major secreted antigen of Mycobacterium tuberculosis.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre - 1 Jan 2000
Mustafa Abu S, Abal Adnan T, Shaban Fatma, El-Shamy Abdulsalam M, Amoudy Hanady A
Abstract excerpt
OBJECTIVE: To identify T-cell epitopes of Ag85B by analysis of its sequence for prediction to bind HLA-DR alleles and evaluate the predicted peptides for recognition by T cells in antigen-induced proliferation assays. MATERIALS/SUBJECTS AND METHODS: The complete sequence of Ag85B was analyzed for HLA-DR binding prediction to 51 HLA-DR alleles by using a virtual matrix-based prediction program (ProPred). Synthetic...
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