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Article

Structure-function analysis of exotoxin A proteins with mutations at histidine 426.

Infection and immunity - 1 Mar 1992

Wick M J, Cook J M, Iglewski B H

Abstract excerpt

Substitution of Tyr for His-426 of Pseudomonas aeruginosa exotoxin A results in a mutant protein with reduced ADP-ribosyltransferase activity (M. J. Wick and B. H. Iglewski, J. Bacteriol. 170:5385-5388, 1988). To investigate the role of His-426 in enzymatic activity, oligonucleotide-directed mutagenesis was used to construct mutant proteins encoding Ala, Glu, Gly, Lys, or Pro at position 426. The effect of these...

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Identifiers

PMID: 1541528
DOI: 10.1128/iai.60.3.1128-1139.1992
PMCID: PMC257604

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Source receipt: pubmed, retrieved 7 Sept 2026.

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