Article
Dynein pulls microtubules without rotating its stalk.
Proceedings of the National Academy of Sciences of the United States of America - 16 Dec 2008
Ueno Hironori, Yasunaga Takuo, Shingyoji Chikako, Hirose Keiko
Abstract excerpt
Dynein is a microtubule motor that powers motility of cilia and flagella. There is evidence that the relative sliding of the doublet microtubules is due to a conformational change in the motor domain that moves a microtubule bound to the end of an extension known as the stalk. A predominant model for the movement involves a rotation of the head domain, with its stalk, toward the microtubule plus end. However,...
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